Know your health from the inside out.

Bisu tracks your dietary health, fat metabolism and hydration in just 2 minutes, and provides daily feedback to help you reach your goals.

Track your results, not your effort.

Dietary health

Tracks pH, an indicator of dietary acid load, at 50x the sensitivity of a urine test strip 

Ketosis & fat metabolism

Tracks the same ketones as a blood test at 10x the sensitivity of a urine test strip

Hydration

Tracks specific gravity and urine color, as an indicator of hydration status

Analyze trends, set goals, take action.

Benefits backed by science.

Achieve optimal ketosis

Bisu is the first device to track BHB ketones in urine, at 10x the sensitivity of an acetoacetate urine test strip

Increase physical endurance 

Alkaline diets are shown to increase anaerobic exercise performance. Bisu’s pH tracking helps keep you in top form

Burn body fat

Bisu lets you track fat loss even when not in full ketosis, by detecting trace quantities of BHB ketones

Improve mood and focus

A loss of even 2% of body water can impair mood and cognition. Bisu helps you stay hydrated and focus

Protect metabolic health

Acidic diets cause metabolic damage and insulin resistance. Bisu helps keep your diet in the right zone

Enhance skin condition

Dietary water intake affects skin water content & physiology. Bisu’s hydration tracking helps keep you at your best

Available for beta testing in 2018 – apply now!

Frequently Asked Questions

(Click toggle on right to expand)

Q: What biomarkers will the device measure?

A: The device will measure BHB ketones (a marker of ketosis and fat metabolism), pH (a marker of dietary acid load), and specific gravity (a marker of hydration). We plan to release other biomarkers in future.

Q: What is the science behind these biomarkers? 

A: Please see the “Research references” section below.

Q:  Why test BHB ketones? Why not use a blood test? Isn’t this just the same as a urine ketone test strip?

Testing BHB ketones in blood is great if you want to know your levels right now – for instance, if you are testing your glucose simultaneously as part of an experiment. However, if you want to track going in and out of ketosis or get a daily indicator of overall ketosis levels, without paying $2-3 each time, we highly recommend testing BHB in urine. This is not the same as using a urine test strip. Test strips are different for two reasons. Firstly, they test acetoacetate, whereas the primary ketone excreted in urine during sustained ketosis is BHB. Secondly, they have a sensitivity of 0.5mmol/L, which is far above the renal ketone threshold of 0.1mmol/L. This is why urine test strips eventually stop working.

Q:  I heard fewer ketones are excreted in urine as the body becomes more efficient at using them. Isn’t that true?

This is a misconception – the amount of acetoacetate which is excreted decreases relative to BHB, but not ketones as a whole (assuming you are at the same level of ketosis). Instead, research indicates that the opposite occurs – the share of ketones utilised is at its highest in the early stages of ketosis, and actually falls after the first 5-7 days before remaining at a relatively constant level. See the “Research references” below for details.

Q: How accurate are the measurements?

A: Measurements are taken using research-grade lab-on-chip technology, and so are far more sensitive than a urine test strip.

Q: How do I perform a test?

A: Remove the colored cap from the sample collection tool and hold the exposed end in the stream of urine. Replace the cap, invert the tool and insert the opposite end into the top of the device. The device will wake up from sleep mode, perform the test and automatically clean itself. Once completed, remove and dispose of the sample collection tool. The results of the test will then be displayed on your Bisu mobile app.

Q: Will the device measure all three biomarkers simultaneously?

A: No – each biomarker has its own separate collection tool. This lets you test only the biomarkers you want to, at the time which is best for you.

Q: How long does each test take?

A: The test procedure takes approx. 2 minutes from start to finish, including the automatic cleaning procedure.

Q: When should I perform tests?

A: For best results, we generally recommend performing tests either (i) first thing in the morning, or (ii) in the evening after dinner. The most important thing is to consistently test at around the same time, to enable the device to build up trend data over time.

Q: How often should I perform tests?

A: For best results, we generally recomend testing once a day.

Q: What does the device come with?

A: The device comes as a set consisting of (i) a base unit, (ii) pack of sample collection tools; (iii) wireless charging station, and (iv) base unit and sample collection tool holder. Replacement sample collection tools will be sent to you each month according to your subscription plan.

Q: How long will the battery last?

A: Assuming you use the device once a day, we expect that the battery will last up to 1 month on a single charge.

Q: How much will the device cost?

A: We are unable to specify this now due to being at the pre-manufacturing stage, but will provide more information as soon as we are able to.

Q: How can I become a beta tester?

A: We will launch our beta testing program during 2018. You can recieve updates on this by joining our mailing list.

Q: When can I pre-order?

A: We expect to open pre-orders in early 2019, and to ship in the same year.

Research references

(Click toggle on right to expand)

(1)  Penders J et. al. Quantitative measurement of ketone bodies in urine using reflectometry. Cain Chem Lab Med. 2005; 43(7): 724-9. [PubMed: 16207132]

(2)  Hassan HM et. al. Determination of beta-hydroxybutyrate in blood and urine using gas chromatography – mass spectrometry. J Anal Toxicol. 2009 Oct; 33(8): 502-7. [PubMed: 19874659]

(3)  Galvin RD et al. Urinary excretion of beta-hydroxybutyrate and acetoacetate during experimental ketosis. Q. J Exp. Physiol Cogn Med Sci. 1968 Apr; 53(2): 181-93. [PubMed: 5185570]

(4)  Welch AA et. al. Urine pH is an indicator of dietary acid-base load, fruit and vegetables and meat intakes. Br J Nutr. 2008 Jun; 99(6): 1335-43. [PubMed: 18042305]

(5)  Ailsa A. Welch. Dipstick measurements of urinary pH have potential for monitoring individual and population dietary behaviors. The Open Nutrition Journal. 2006, 2, 63-67.

(6)  John M. Berardi et. al. Plant based dietary supplement increased urinary pH. J Int Soc Sports Nutr. 2008; 5:20. [PubMed: 18990209]

(7)  A. Kanbara, Y. Miura et. al. Effect of urine pH changed by dietary intervention on uric acid clearance mechanism of pH-dependent excretion of urinary uric acid. Nutr J. 2012; 11:39. [PubMed: 22676161]

(8)  Remer, T. & Manz, F. Potential renal acid load of foods and its influence on urine pH. J Am Diet Assoc. 1995 Jul; 95(7): 791-7. [PubMed: 7797810]

(9)  Akter S et. al. High dietary acid load is associated with insulin resistance: The Furukawa Nutrition and Health Study. Clin Nutr. 2016 Apr; 35(2): 453-9. [PubMed: 25863769]

(10)  Williams RS et. al. The role of dietary acid load and mild metabolic acidosis in insulin resistance in humans. Biochimie. 2016 May; 124:171-7. [PubMed: 26363101]

(11)  Williams RS et. al. Dietary acid load, metabolic acidosis and insulin resistance – Lessons from cross-sectional and overfeeding studies in humans. Clin Nutr. 2016 Oct; 35(5): 1084-90 [PubMed: 26299332]

(12)  Sajjad Khalili Moghadam et. al. Association between dietary acid load and insulin resistance: Tehran lipid and glucose study. Prev. Nutr. Food Sci. 2016; 21(2): 104-109. [PubMed: 27390726]

(13)  Caciano SL et. al. Effects of dietary acid load on exercise metabolism and anaerobic exercise performance. J Sports Sci Med. 2015 May 8; 14(2): 364-71. [PubMed: 25983586]

(14)  Caciano SL et. al. Systemic acid load from the diet affects maximal exercise respiratory exchange ratio. J Sports Sci Med. 2015 May 8;14(2):364-71. [PubMed: 25983586]

(15)  Nesli Ersoy et. al. Assessment of hydration status of elite young male soccer players with different  methods and new approach method of substitute urine strip. J Int Soc Sports Nutr. 2016; 13(1): 34. [PubMed: 27594812]

(16)  Hahn RG et. al. An aggregate urine analysis tool to detect acute dehydration. Int J Sport Nutr Exerc Metab. 2013 Aug; 23(4): 303-11. [PubMed: 23994895]

(17)  Pross N et. al. Influence of progressive fluid restriction on mood and physiological markers of dehydration in women. Br J Nutr. 2013 Jan 28;109(2):313-21. [PubMed: 22716932]

(18)  Armstrong LE. Addressing hydration status – the elusive gold standard. J Am Coll Nutr. 2007 Oct; 26 (5 Suppl): 575S-584S. [PubMed: 17921468]

(19)  Popowski LA et. al. Blood and urinary measures of hydration status during progress acute dehydration. Med Sci Sports Exerc. 2001 May; 33(5): 747-53. [PubMed: 11323543]

(20)  Benton D et. al. Do small differences in hydration status affect mood and mental performance? Nutr Rev. 2015 Sep; 73 Suppl 2: 83-96. [PubMed: 26290294]

(21)  Riebl SK et. al. The hydration equation: update on water balance and cognitive performance. ACSMs Health Fit J. 2013 Nov; 17(6): 21-28. [PubMed: 25346594]

(22)  Ganio MS et. al. Mild dehydration impairs cognitive performance and mood of men. Br J Nutr. 2011; 106(10): 1535-43. [PubMed: 21736786]

(23)  Palma ML et. al. Positive impact of dietary water on in vivo epidermal water physiology. Skin Res Technol. 2015 Nov; 21(4): 413-8. [PubMed: 26058417]

(24)  Lidia Palma et. al. Dietary water affects human skin hydration and biomechanics. Clin Cosmet Investig Dermatol. 2015; 8: 413-421. [DOI: 10.1111/srt.12208]

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