The power of a lab analyzer, on your bathroom shelf.
Every day we flush precious data on our health down the toilet. Capture this data with Bisu.
Track your results, not your effort.
Dietary acid load
Tracks pH as an indicator of dietary acid load
Ketosis & fat burning
Tracks BHB and AcAc, at 10x the sensitivity of a urine strip
Tracks sodium and potassium as an indicator of intake
Tracks specific gravity as an indicator of hydration status
Analyze trends, set goals, take action.
Become the best version of yourself.
Achieve optimal ketosis
Track the same ketones as a blood reader without having to prick yourself
Increase physical endurance
Keep your diet in the optimal zone for anaerobic exercise performance
Burn body fat
Become a fat burning machine by tracking ketosis and caloric deficit
Improve mood and focus
Avoid a loss of even 2% body water impairing your mood and cognition
Protect metabolic health
Avoid metabolic damage and insulin resistance caused by an acidic diet
Enhance skin condition
Make sure your skin has the hydration it needs to stay at its best
Beta test in 2018 – be the first to know!
Frequently Asked Questions
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Q: What biomarkers will the device measure?
A: The device will initially measure pH (a marker of dietary acid load), BHB and AcAc ketones (a marker of ketosis and fat metabolism), sodium and potassium (a marker of dietary intake), specific gravity (a marker of hydration), and creatinine (biomarker by which all readings are adjusted).
Q: What is the science behind these biomarkers?
A: Please see the “Research references” section below.
Q: Why test BHB ketones? Why not use a blood test? Isn’t this just the same as a urine ketone test strip?
Testing BHB ketones in blood is great if you want to know your levels right now (e.g. if you are testing your glucose simultaneously as part of an experiment). However, your blood ketone levels also fluctuate throughout the day, you have to prick your finger each time, and it will cost you $1-2 just to test this biomarker. Bisu is the first device which enables you to test both BHB and AcAc in urine simultaneously, at a sensitivity of 0.1mmol/L, which is also the renal threshold for ketones. Urine test strips are very different because they only test AcAc (whereas the primary ketone excreted in urine during sustained ketosis is BHB) and have a low sensitivity of 0.5mmolL. This is why urine test strips are inaccurate.
Q: I heard fewer ketones are excreted in urine as the body becomes more efficient at using them. Isn’t that true?
This is a misconception – the amount of AcAc which is excreted decreases relative to BHB, but not ketones as a whole (assuming you are at the same level of ketosis). Instead, research indicates that the opposite occurs – the share of ketones utilised is at its highest in the early stages of ketosis, and actually falls after the first 5-7 days before remaining at a relatively constant level. See the “Research references” below for details.
Q: How accurate are the measurements?
A: The device provides quantitative measurements using research grade lab-on-a-chip technology.
Q: How do I perform a test?
A: Remove the colored cap from the sample collection tool and hold the exposed end in the stream of urine. Replace the cap, invert the tool and insert the opposite end into the top of the device. The device will wake up from sleep mode, perform the test and automatically clean itself. Once completed, remove and dispose of the sample collection tool. The results of the test will then be displayed on your Bisu mobile app.
Q: Will the device measure all biomarkers simultaneously?
A: Yes – one test, multiple biomarkers.
Q: How long does each test take?
A: The test procedure takes approximately two minutes from start to finish, including the automatic cleaning procedure.
Q: When should I perform tests?
A: For best results, we generally recommend performing tests either (i) first thing in the morning, or (ii) in the evening after dinner. The most important thing is to consistently test at around the same time, to enable the device to build up trend data over time.
Q: How often should I perform tests?
A: For best results, we generally recomend testing once a day, but once every other day will also give good results when testing in the morning.
Q: What does the device come with?
A: The device comes as a set consisting of (i) a base unit, (ii) pack of sample collection tools; (iii) wireless charging station, and (iv) base unit and sample collection tool holder. Replacement sample collection tools will be sent to you each month according to your subscription plan.
Q: How long will the battery last?
A: Assuming you use the device once a day, we expect that the battery will last up to one month on a single charge.
Q: How much will the device cost?
A: We are unable to specify this now due to being at the pre-manufacturing stage, but will provide more information as soon as we are able to.
Q: How can I become a beta tester?
A: We will launch our beta testing program during 2018. You can recieve updates on this by joining our mailing list.
Q: When can I order the device?
A: We expect to open orders in early 2019, and to ship in the same year.
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(1) Penders J et. al. Quantitative measurement of ketone bodies in urine using reflectometry. Cain Chem Lab Med. 2005; 43(7): 724-9. [PubMed: 16207132]
(2) Hassan HM et. al. Determination of beta-hydroxybutyrate in blood and urine using gas chromatography – mass spectrometry. J Anal Toxicol. 2009 Oct; 33(8): 502-7. [PubMed: 19874659]
(3) Galvin RD et al. Urinary excretion of beta-hydroxybutyrate and acetoacetate during experimental ketosis. Q. J Exp. Physiol Cogn Med Sci. 1968 Apr; 53(2): 181-93. [PubMed: 5185570]
(4) Welch AA et. al. Urine pH is an indicator of dietary acid-base load, fruit and vegetables and meat intakes. Br J Nutr. 2008 Jun; 99(6): 1335-43. [PubMed: 18042305]
(5) Ailsa A. Welch. Dipstick measurements of urinary pH have potential for monitoring individual and population dietary behaviors. The Open Nutrition Journal. 2006, 2, 63-67.
(6) John M. Berardi et. al. Plant based dietary supplement increased urinary pH. J Int Soc Sports Nutr. 2008; 5:20. [PubMed: 18990209]
(7) A. Kanbara, Y. Miura et. al. Effect of urine pH changed by dietary intervention on uric acid clearance mechanism of pH-dependent excretion of urinary uric acid. Nutr J. 2012; 11:39. [PubMed: 22676161]
(8) Remer, T. & Manz, F. Potential renal acid load of foods and its influence on urine pH. J Am Diet Assoc. 1995 Jul; 95(7): 791-7. [PubMed: 7797810]
(9) Akter S et. al. High dietary acid load is associated with insulin resistance: The Furukawa Nutrition and Health Study. Clin Nutr. 2016 Apr; 35(2): 453-9. [PubMed: 25863769]
(10) Williams RS et. al. The role of dietary acid load and mild metabolic acidosis in insulin resistance in humans. Biochimie. 2016 May; 124:171-7. [PubMed: 26363101]
(11) Williams RS et. al. Dietary acid load, metabolic acidosis and insulin resistance – Lessons from cross-sectional and overfeeding studies in humans. Clin Nutr. 2016 Oct; 35(5): 1084-90 [PubMed: 26299332]
(12) Sajjad Khalili Moghadam et. al. Association between dietary acid load and insulin resistance: Tehran lipid and glucose study. Prev. Nutr. Food Sci. 2016; 21(2): 104-109. [PubMed: 27390726]
(13) Caciano SL et. al. Effects of dietary acid load on exercise metabolism and anaerobic exercise performance. J Sports Sci Med. 2015 May 8; 14(2): 364-71. [PubMed: 25983586]
(14) Caciano SL et. al. Systemic acid load from the diet affects maximal exercise respiratory exchange ratio. J Sports Sci Med. 2015 May 8;14(2):364-71. [PubMed: 25983586]
(15) Nesli Ersoy et. al. Assessment of hydration status of elite young male soccer players with different methods and new approach method of substitute urine strip. J Int Soc Sports Nutr. 2016; 13(1): 34. [PubMed: 27594812]
(16) Hahn RG et. al. An aggregate urine analysis tool to detect acute dehydration. Int J Sport Nutr Exerc Metab. 2013 Aug; 23(4): 303-11. [PubMed: 23994895]
(17) Pross N et. al. Influence of progressive fluid restriction on mood and physiological markers of dehydration in women. Br J Nutr. 2013 Jan 28;109(2):313-21. [PubMed: 22716932]
(18) Armstrong LE. Addressing hydration status – the elusive gold standard. J Am Coll Nutr. 2007 Oct; 26 (5 Suppl): 575S-584S. [PubMed: 17921468]
(19) Popowski LA et. al. Blood and urinary measures of hydration status during progress acute dehydration. Med Sci Sports Exerc. 2001 May; 33(5): 747-53. [PubMed: 11323543]
(20) Benton D et. al. Do small differences in hydration status affect mood and mental performance? Nutr Rev. 2015 Sep; 73 Suppl 2: 83-96. [PubMed: 26290294]
(21) Riebl SK et. al. The hydration equation: update on water balance and cognitive performance. ACSMs Health Fit J. 2013 Nov; 17(6): 21-28. [PubMed: 25346594]
(22) Ganio MS et. al. Mild dehydration impairs cognitive performance and mood of men. Br J Nutr. 2011; 106(10): 1535-43. [PubMed: 21736786]
(23) Palma ML et. al. Positive impact of dietary water on in vivo epidermal water physiology. Skin Res Technol. 2015 Nov; 21(4): 413-8. [PubMed: 26058417]
(24) Lidia Palma et. al. Dietary water affects human skin hydration and biomechanics. Clin Cosmet Investig Dermatol. 2015; 8: 413-421. [DOI: 10.1111/srt.12208]
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